The secular variation in the global geomagnetic field was analyzed in terms of the annual differences in monthly means by using the hourly mean data from 18 foreign (outside China) observatories of the World Data Center (WDC) for Geomagnetism from January 2010 to January 2020 as well as 9 observatories in the Geomagnetic Network of China from Janua
The Contentious Debate over the Language Literature Division
In the early 20th century literature was woven into language curriculum to endorse learners to acquire language structures and perform drills successfully.The actual use of the target language upstaged grammar instruction as the primary focus of language learning in the fields of language pedagogy.In the late 1960s and 1970s literature fell into di
National Variations in the Work-Up, Investigation, and Surgical Management of Ductal Carcinoma In Situ of the Breast across Canadian Surgeons
Variation in the management of Ductal Carcinoma In Situ (DCIS) of the breast occur at both national and international levels.The aim of this study HEALTHY HAIR W JOJOBA is to determine the degree of, and reasons behind, this variation in the workup and treatment of DCIS among Canadian surgeons.We developed a 35-question survey involving the pre-, p
Puff Bars, Tobacco Policy Evasion, and Nicotine Dependence: Content Analysis of Tweets
BackgroundPuff Bars are e-cigarettes that continued marketing flavored products by exploiting the Tea Cosy US Food and Drug Administration exemption for disposable devices.ObjectiveThis study aimed to examine discussions related to Puff Bar on Twitter to identify tobacco regulation and policy themes as well as unanticipated outcomes of regulatory l
Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy
Activation of co-stimulatory pathways in cytotoxic T lymphocytes expressing chimeric antigen receptors (CARs) have proven to boost effector activity, tumor rejection and long-term T cell persistence.When using antigen-specific T cell receptors (TCR) instead of CARs, the lack of co-stimulatory signals hampers robust antitumoral response, hence limit